Metal-Free Radical Annulation-Hydrofunctionalization of 1,6-Enynes for Stereoselective Synthesis of (E)-1-Indanones
Two metal-free radical annulation-hydrofunctionalization cascades of 1,6-enynes have been established, enabling the complete stereoselectivity to access a wide range of functionalized (E)-1-indanones with moderate to good yields. The reaction pathways involve in situ-generated P- or S-centered radic...
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Published in | Asian journal of organic chemistry Vol. 9; no. 7; pp. 1040 - 1044 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.07.2020
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Subjects | |
Online Access | Get more information |
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Summary: | Two metal-free radical annulation-hydrofunctionalization cascades of 1,6-enynes have been established, enabling the complete stereoselectivity to access a wide range of functionalized (E)-1-indanones with moderate to good yields. The reaction pathways involve in situ-generated P- or S-centered radical-triggered alpha,beta-conjugated addition/5-exo-dig cyclization/H-abstraction sequence, allowing direct and versatile protocols for stereoselective construction of 1-indanone scaffolds with high functional group tolerance and wide substrate scope. |
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ISSN: | 2193-5807 2193-5815 |
DOI: | 10.1002/ajoc.202000197 |