Radical‐Mediated Approaches for the Synthesis of Thiolactones
In this review we discuss the diverse synthetic approaches and methodologies which have been utilized for the preparation of small and medium ring thiolactones via radical‐mediated processes. We provide a brief overview of the major current applications and uses of thiolactones in disparate fields o...
Saved in:
Published in | European journal of organic chemistry Vol. 2021; no. 37; pp. 5320 - 5334 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Weinheim
Wiley Subscription Services, Inc
07.10.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In this review we discuss the diverse synthetic approaches and methodologies which have been utilized for the preparation of small and medium ring thiolactones via radical‐mediated processes. We provide a brief overview of the major current applications and uses of thiolactones in disparate fields of study and outline a selection of representative methods which have been employed for the preparation of compounds containing this structural motif, with a concise consideration of the conditions employed, the key intermediates formed and the mechanism of the transformations, where pertinent. Reaction classification has been broadly divided into two distinct classes: those in which the key bond forming step is an intermolecular radical process, and those in which it is an intramolecular process (radical cyclization). Both of these reaction classes may be further subdivided into processes that proceed via a carbon‐centered (C‐centered) radical, and those that proceed through a thiyl/sulfur‐centered (S‐centered) radical.
Thiolactones represent an interesting and robust class of often overlooked heterocyclic compounds with applications in disparate fields. Herein we discuss the radical based approaches and strategies which have been developed and implemented for their synthesis. |
---|---|
ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.202100996 |