Visible Light‐Mediated Defluorination to Access 1,1‐Difluoro‐1,3‐Enynes

Herein, a visible light‐mediated defluorination reaction to access 1,1‐difluoro‐1,3‐enynes is described. Compared with previous studies, this protocol employs more readily accessible acids as a radical precursor under redox‐neutral conditions. Moreover, the reaction exhibits high compatibility with...

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Published inAdvanced synthesis & catalysis Vol. 366; no. 10; pp. 2246 - 2251
Main Authors Wang, Xu, Huang, Wei, Zhang, Feng‐Hua
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 21.05.2024
Wiley Subscription Services, Inc
Subjects
1,1-difluoro-1,3-enynes
acid
Amino acids
Chemistry
Chemistry, Applied
Chemistry, Organic
Defluorination
metal free
photoredox catalysis
Physical Sciences
redox-neutral
Science & Technology
acid
redox-neutral
FLUORINE
photoredox catalysis
metal free
1,1-difluoro-1,3-enynes
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Summary:Herein, a visible light‐mediated defluorination reaction to access 1,1‐difluoro‐1,3‐enynes is described. Compared with previous studies, this protocol employs more readily accessible acids as a radical precursor under redox‐neutral conditions. Moreover, the reaction exhibits high compatibility with diverse primary, secondary and tertiary acids, especially natural amino acids and drug‐derived acids. Preliminary mechanistic investigations reveal that a radical pathway is involved in the catalytic cycle.
Bibliography:ObjectType-Article-1
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content type line 14
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400183