Layer‐By‐Layer Modified Superparamagnetic Iron Oxide Nanoparticles with Stimuli‐Responsive Drug Release Properties

• Published in: Macromolecular chemistry and physics Vol. 220; no. 4
• Main Authors: Akbar, Majid, Cagli, Eda, Erel‐Göktepe, Irem
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.02.2019
• Subjects: Coating; Doxorubicin; Drug carriers; drug delivery; Drug delivery systems; Iron oxides; layer‐by‐layer self‐assembly; Magnetic saturation; Nanoparticles; poly(2‐alkyl‐2‐oxazoline)s; Polymer coatings; stimuli responsive; superparamagenetic iron oxide nanoparticles; Tannic acid; Ultrasonic methods; Ultrasonic testing
• ISSN: 1022-1352; 1521-3935
• DOI: 10.1002/macp.201800422

Superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized through ultrasound based coprecipitation method. SPIONs are coated with poly(2‐isopropyl‐2‐oxazoline) (PIPOX) and tannic acid (TA) in a layer‐by‐layer (LbL) fashion at pH 4 and 25 °C. PIPOX/TA coated SPIONs are then loaded with doxorubicin (DOX) at pH 7.5 and 25 °C. DOX release from LbL‐coated SPIONs is examined at pH 7.5 and pH 6 at 25 °C, 37 °C, and 42 °C. LbL‐coated SPIONs exhibit dual responsive behavior and release the greatest amount of DOX at pH 6 and 42 °C. Increasing layer number decreases the colloidal stability and saturation magnetization. Superparamagnetic behavior of SPIONs retains after coating. Overall, this study shows an alternative strategy to modify the surface of SPIONs with a dual responsive polymer coating which is capable of releasing DOX at moderately acidic pH of 6 within a physiologically related temperature range. Besides, it generates fundamental knowledge for further development of SPIONs‐based drug carriers. Superparamagnetic iron oxide nanoparticles (SPIONs) are layer‐by‐layer (LbL) modified using stimuli‐responsive polymers. These LbL‐coated SPIONs are capable of releasing doxorubicin (DOX) at acidic pH within a physiologically related temperature range.