Discovery of Anti-MRSA Secondary Metabolites from a Marine-Derived Fungus Aspergillus fumigatus

• Published in: Marine drugs Vol. 20; no. 5; p. 302
• Main Authors: Zhang, Rui, Wang, Haifeng, Chen, Baosong, Dai, Huanqin, Sun, Jingzu, Han, Junjie, Liu, Hongwei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.04.2022; MDPI
• Subjects: Anti-Bacterial Agents - chemistry; Antibacterial activity; Antibiotic resistance; Antibiotics; Aspergillus fumigatus; Biological activity; Cancer; Candida albicans; Carbon; chemical diversity; chemical ecology; Circular dichroism; Dichroism; Disease resistance; Drug resistance; Fungi; Hatching; Hydrocarbons; Mass spectrometry; Mass spectroscopy; Metabolites; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Minimum inhibitory concentration; NMR; Nosocomial infections; Nuclear magnetic resonance; Ova; Pathogens; Secondary metabolites; Staphylococcus aureus; Staphylococcus infections; chemical ecology; methicillin-resistant Staphylococcus aureus; Aspergillus fumigatus; chemical diversity
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md20050302

Methicillin-resistant (MRSA), a WHO high-priority pathogen that can cause great harm to living beings, is a primary cause of death from antibiotic-resistant infections. In the present study, six new compounds, including fumindoline A-C ( - ), 12 , 13 -hydroxy-asperfumigatin ( ), 2- -tryptoquivaline F ( ) and penibenzophenone E ( ), and thirty-nine known ones were isolated from the marine-derived fungus H22. The structures and the absolute configurations of the new compounds were unambiguously assigned by spectroscopic data, mass spectrometry (MS), electronic circular dichroism (ECD) spectroscopic analyses, quantum NMR and ECD calculations, and chemical derivatizations. Bioactivity screening indicated that nearly half of the compounds exhibit antibacterial activity, especially compounds and , and - showed excellent antimicrobial activities against MRSA, with minimum inhibitory concentration (MIC) values ranging from 1.25 to 2.5 μM. In addition, compound showed moderate inhibitory activity against (MIC: 25 μM), compound showed moderate inhibitory activity against (MIC: 50 μM), and compound showed strong inhibitory activity against the hatching of a egg (IC : 2.5 μM).