Rhodium(III)-Catalyzed Cross-Coupling of Sulfoxonium Ylides with Quinoline-8-carboxaldehydes for Synthesis of Quinoline-1,3-diketones
Herein, we report a protocol for rhodium(III)-catalyzed aldehydic C(sp(2))-H acylmethylation reactions of quinoline-8-carboxaldehydes using sulfoxonium ylides as carbene precursors to afford 1,3-diketones, which readily tautomerized to their enol forms. We determined the reaction mechanism by synthe...
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Published in | Asian journal of organic chemistry Vol. 10; no. 1; pp. 176 - 179 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.01.2021
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Subjects | |
Online Access | Get more information |
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Summary: | Herein, we report a protocol for rhodium(III)-catalyzed aldehydic C(sp(2))-H acylmethylation reactions of quinoline-8-carboxaldehydes using sulfoxonium ylides as carbene precursors to afford 1,3-diketones, which readily tautomerized to their enol forms. We determined the reaction mechanism by synthesizing the key intermediate, a five-membered-ring acylrhodium species. |
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ISSN: | 2193-5807 2193-5815 |
DOI: | 10.1002/ajoc.202000581 |