Pattern of antiendothelial cell antibodies in patients with chronic obstructive pulmonary disease

• Published in: Egyptian Journal of Bronchology Vol. 11; no. 3; pp. 203 - 208
• Main Authors: Mohamed, Randa Salah Eldin, Elbatanony, Mahmoud Mohamed, Mohamed, Abeer Salah Eldin, Elhadary, Sherif
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2017; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Antibodies; antiendothelial cell antibodies; Chronic obstructive pulmonary disease; Cor pulmonale; Endothelium; Lung diseases, Obstructive; Medicine & Public Health; Original Article; pulmonary hypertension; Viral antibodies; antiendothelial cell antibodies; pulmonary hypertension; chronic obstructive pulmonary disease
• ISSN: 1687-8426; 2314-8551
• DOI: 10.4103/1687-8426.203801

Background Autoimmune mechanisms have been recently recognized as being partly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Circulating autoantibodies have been detected in patients with COPD. Objectives The aim of this study was to estimate the level of antiendothelial cell antibodies (AECA) in COPD patients in the various GOLD stages. Patients and methods A comparative study assessed the level of AECA in three groups. COPD patients without cor pulmonale (18), with cor pulmonale (12), and the control group (10), from Beni-Suef University Hospital. Each group underwent background questionnaires and BMI measures. Enzyme-linked immunosorbent assay was used to measure the level of AECA in serum (ng/ml). Right ventricular systolic pressure (mm Hg) was measured in COPD patients with cor pulmonale. Results The studied groups consisted of male patients (age: 50–80 years). BMI was significantly lower (20.36) in the COPD group with cor pulmonale. Spirometry forced expiratory volume and forced expiratory volume/forced vital capacity ratios showed significantly lower levels among the COPD patients without cor pulmonale. AECA showed a lower level in the control group (26.25) compared with the COPD without cor pulmonale (57.87) and much lowered when compared to cor pulmonale group (71.47). The level of AECD was higher in the patients in third (74.78) and fourth stages (79.10) compared with those in the second stage (58.75). Conclusion There is a much higher level of AECA in COPD patients with cor pulmonale and in advanced stages in comparison with patients without cor pulmonale and at early stages, and a significant positive correlation was found between AECA levels and right ventricular systolic pressure.