Aza‐Michael Reaction: A Decade Later – Is the Research Over?

• Published in: European journal of organic chemistry Vol. 26; no. 26
• Main Author: Yu. Rulev, Alexander
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 08.07.2023
• Subjects: Amines; aza-Michael addition; catalysis; Ionic liquids; Lewis acid; Michael acceptors; Michael reaction; Nucleophiles; Organic chemistry; synthetic methods; Transition metals

The 1,4‐conjugated addition of nitrogen centered nucleophiles to electron‐deficient alkenes, historically called the aza‐Michael addition, is one of the most significant and widely used reactions in modern synthetic organic chemistry. In the last decade, great progress has been made in this field na...