Aza‐Michael Reaction: A Decade Later – Is the Research Over?

The 1,4‐conjugated addition of nitrogen centered nucleophiles to electron‐deficient alkenes, historically called the aza‐Michael addition, is one of the most significant and widely used reactions in modern synthetic organic chemistry. In the last decade, great progress has been made in this field na...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 26; no. 26
Main Author Yu. Rulev, Alexander
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 08.07.2023
Subjects
Amines
aza-Michael addition
catalysis
Ionic liquids
Lewis acid
Michael acceptors
Michael reaction
Nucleophiles
Organic chemistry
synthetic methods
Transition metals
Online AccessGet full text

Cover

More Information
Summary:The 1,4‐conjugated addition of nitrogen centered nucleophiles to electron‐deficient alkenes, historically called the aza‐Michael addition, is one of the most significant and widely used reactions in modern synthetic organic chemistry. In the last decade, great progress has been made in this field namely in the development of various catalytic systems. Fundamental advances involve the use of transition metal catalysts, organocatalysts, enzymes, ionic liquids, Brønsted and Lewis acids and bases. This Review aims to critically analyze the results of research into the reactions of aliphatic and aromatic amines with Michael acceptors. Since its discovery, the aza‐Michael reaction has been the subject of intense research. This Review summarizes the strategies for conjugate nucleophilic addition of aliphatic and aromatic amines to electron‐deficient alkenes that have been developed in the last decade.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202300451