Safety as a Factor in Reaction Development: Considerations of Sensitization Potential with Amide Bond Forming Reagents

In response to an increased awareness of sensitization issues with amide bond forming agents, a detailed toxicological analysis of this broad family of reagents was undertaken which led to a quantitative ranking of the sensitization potential of these commonly used compounds. This data enables occup...

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Bibliographic Details
Published inHelvetica chimica acta Vol. 106; no. 11
Main Authors George, David T., Williams, Michael J., Beutner, Gregory L.
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.11.2023
Wiley Subscription Services, Inc
Subjects
amides
carbodiimide
Chemistry
Chemistry, Multidisciplinary
heterocycles
Physical Sciences
Reagents
Risk reduction
Science & Technology
toxicology
toxicology
PEPTIDE COUPLING REAGENTS
ALLERGIC CONTACT-DERMATITIS
amides
heterocycles
carbodiimide
HATU
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Summary:In response to an increased awareness of sensitization issues with amide bond forming agents, a detailed toxicological analysis of this broad family of reagents was undertaken which led to a quantitative ranking of the sensitization potential of these commonly used compounds. This data enables occupational toxicologists to guide the safer use of these reagents in the laboratory, but it also provides an opportunity for chemists working on reaction development, optimization and scale‐up. To illustrate this, one of the strongest sensitizers, EDAC, is compared with the performance of one of the weakest, TCFH, showing the potential of this data for minimizing risks for researchers when using this family of reagents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.202300140