Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 309; no. 8; pp. R855 - R863
• Main Authors: Williamson, David L., Dungan, Cory M., Mahmoud, Abeer M., Mey, Jacob T., Blackburn, Brian K., Haus, Jacob M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.10.2015
• Subjects: Adult; Case-Control Studies; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Female; Glucose; Humans; Insulin; Insulin - pharmacology; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Musculoskeletal system; Obesity; Obesity, Diabetes and Energy Homeostasis; Phosphorylation; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; mTOR; glucocorticoid; signaling; insulin resistance

The objective of this study was to establish whether alterations in the REDD1-mTOR axis underlie skeletal muscle insensitivity to insulin in Type 2 diabetic (T2D), obese individuals. Vastus lateralis muscle biopsies were obtained from lean, control and obese, T2D subjects under basal and after a 2-h...