Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives

The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl 4 -induced rat hepatitis showed...

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Published inRussian journal of bioorganic chemistry Vol. 45; no. 6; pp. 558 - 565
Main Authors Kazakova, O. B., Smirnova, I. E., Medvedeva, N. I., Lopatina, T. V., Chudov, I. V., Sharipov, A. R., Ziganshin, A. S., Thao, Tran Thi Phuong
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2019
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Carbon tetrachloride
Hepatitis
Life Sciences
Organic Chemistry
lupanes
dipterocarpol
dammaranes
triterpenoids
betulin
hepatoprotective activity
acylation
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Summary:The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl 4 -induced rat hepatitis showed that the activities of the betulin bisacylates 3β,28-bis- О -nicotinate and 3β,28-bis- О -isonicotinate were higher than that of monoacylate 28- О -isonicotinate. 3β-Hydroxydipterocarpol was found to be the most active among triterpenoids of the dammarane type.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162019050030