Thirty years after the Chernobyl accident: Molecular genetic mechanisms of carcinogenesis of the thyroid gland

The review presents data on the basic molecular genetic mechanisms of formation of papillary thyroid carcinoma. The participation of ionizing radiation in the cancer pathogenesis was analyzed. The role of tumor microenvironment, inflammation, and nuclear transcription factor NF-κB in the initiation...

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Bibliographic Details
Published inCytology and genetics Vol. 50; no. 6; pp. 366 - 371
Main Authors Tronko, N. D., Pushkarev, V. M.
Format Journal Article
LanguageEnglish
Published New York Allerton Press 01.11.2016
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Carcinogenesis
Human Genetics
Ionizing radiation
Papillary thyroid carcinoma
Thyroid
Thyroid cancer
oncogenes
NF-κB
thyroid gland
papillary thyroid carcinoma
inflammation
ionizing radiation
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Summary:The review presents data on the basic molecular genetic mechanisms of formation of papillary thyroid carcinoma. The participation of ionizing radiation in the cancer pathogenesis was analyzed. The role of tumor microenvironment, inflammation, and nuclear transcription factor NF-κB in the initiation and development of papillary thyroid carcinoma was shown.
ISSN:0095-4527
1934-9440
DOI:10.3103/S0095452716060098