Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy

The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force...

Full description

Saved in:
Bibliographic Details
Published inTechnical physics letters Vol. 43; no. 1; pp. 85 - 87
Main Authors Khalisov, M. M., Penniyaynen, V. A., Esikova, N. A., Ankudinov, A. V., Krylov, B. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2017
Springer Nature B.V
Subjects
Classical and Continuum Physics
Mechanical properties
Physics
Physics and Astronomy
Online AccessGet full text

Cover

More Information
Summary:The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force microscopy, it is established that exposure to ouabain, in contrast to the impact of comenic acid, leads to a hardening of the neuron soma. This suggests that the receptor-coupled signal transmission to the cell genome is carried out through mechanisms that are different from the transducer-coupled signal pathways.
ISSN:1063-7850
1090-6533
DOI:10.1134/S1063785017010072