Copper(II) Complexes with 5-Nitro-2-furoic Acid: Synthesis, Structure, Thermal Properties, and Biological Activity

• Published in: Russian journal of inorganic chemistry Vol. 67; no. 10; pp. 1545 - 1556
• Main Authors: Koshenskova, K. A., Lutsenko, I. A., Nelyubina, Yu. V., Primakov, P. V., Aliev, T. M., Bekker, O. B., Khoroshilov, A. V., Mantrov, S. N., Kiskin, M. A., Eremenko, I. L.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.10.2022; Springer Nature B.V
• Subjects: Antiinfectives and antibacterials; Biological activity; Biological properties; Chemistry; Chemistry and Materials Science; Coordination Compounds; Copper; Furoic acid; Inorganic Chemistry; Ligands; Nitrogen dioxide; Solid phases; Spectrum analysis; Stability analysis; Thermal analysis; Thermal stability; Thermodynamic properties; copper(II) complexes; crystal structure; synchronous thermal analysis; biological activity; 5-nitro-2-furoic acid
• ISSN: 0036-0236; 1531-8613
• DOI: 10.1134/S003602362270005X

Reaction of copper(II) acetate with 5-nitro-2-furoic acid (NO 2 -Hfur) and N-donor ligands 2,2'‑bipyridine (bpy) and pyridine (py) has resulted in complexes [Cu(NO 2 -fur) 2 (H 2 O) 2 ]·2H 2 O ( I ), [Cu(NO 2 -fur) 2 (py) 2 (H 2 O)] ( II ), and binuclear [Cu 2 (NO 2 -fur) 4 (bpy) 2 ]·H 2 O ( III ) whose structure was determined by X‑ray diffraction study. Cation Cu 2+ is in square-planar ( I ) or square-pyramidal ( II , III ) environment and has CN(Cu) = 4 ( I ) or 5 ( II , III ), respectively. Stability of complexes I – III in solid phase has been determined by synchronous thermal analysis, stability in solutions has been studied by electronic absorption spectroscopy. Compounds I and II are thermally stable (>100°С). The presence of nitro group in the complexes causes strong exothermal effects, whose intensity is leveled by donor ligand. The storage of solutions of the compounds in 5% glucose solution and 0.9% NaCl for 2 days according to UV spectroscopy causes no their degradation. Biological activity of complexes I – III was studied in vitro toward non-pathogenic strain M. smegmatis (behaves as a model for M. tuberculosis ); antimicrobial activity of compound II toward a number of Gram-positive and Gram-negative bacteria has been investigated.