A dual stimuli-responsive amphiphilic polymer: reversible self-assembly and rate-controlled drug release
We report the dual stimuli-responsive self-assembly and rate-controlled drug release of a novel functionalized PEG amphiphilic polymer ( FcC 11 AzoPEG ) in aqueous solution. The novel FcC 11 AzoPEG amphiphilic polymer was synthesized by the esterification reaction of poly (ethylene glycol) methyl et...
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Published in | Colloid and polymer science Vol. 295; no. 10; pp. 1851 - 1861 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.10.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | We report the dual stimuli-responsive self-assembly and rate-controlled drug release of a novel functionalized PEG amphiphilic polymer (
FcC
11
AzoPEG
) in aqueous solution. The novel
FcC
11
AzoPEG
amphiphilic polymer was synthesized by the esterification reaction of poly (ethylene glycol) methyl ether (PEG) and 4-(4′-(11-ferrocenyl-undecanoxy)) azobenzoic acid. The azobenzene (Azo) and ferrocene (Fc) moieties respectively afford the polymer a slow photo-response and a fast redox-response. Upon exposure to different stimuli (light irradiation, redox reaction, and a combination of light irradiation and redox reaction),
FcC
11
AzoPEG
in aqueous solution can reversibly self-assemble into various nanostructures and also disassemble either slowly by light irradiation or fast by redox reaction in an appropriate concentration range. Moreover, the drug release from the drug-loaded micelles can be precisely controlled by different stimuli: a slow release rate and a small amount of release for UV irradiation, a fast rate and a medium amount of release for oxidation by Fe
2
(SO
4
)
3
, and a large amount of release for the combined stimulation of UV irradiation and oxidation by Fe
2
(SO
4
)
3.
This work not only demonstrates the effect of stimuli-induced amphiphilicity change of functional groups on the solution aggregation behavior of functionalized PEG amphiphilic polymers but also provides a useful smart system with great potential application in drug delivery.
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ISSN: | 0303-402X 1435-1536 |
DOI: | 10.1007/s00396-017-4156-z |