Simple and efficient approach for improved cytocompatibility and faster degradation of electrospun polycaprolactone fibers

• Published in: Polymer bulletin (Berlin, Germany) Vol. 76; no. 3; pp. 1333 - 1347
• Main Authors: Bhaskaran, Aswathy, Prasad, Tilak, Kumary, T. V., Anil Kumar, P. R.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2019; Springer Nature B.V
• Subjects: Biocompatibility; Cell adhesion; Cell adhesion & migration; Cell growth; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chloride; Complex Fluids and Microfluidics; Contact angle; Cytotoxicity; Degradation; Fibers; Fibroblasts; Fourier transforms; Morphology; Organic Chemistry; Original Paper; Penicillin; Physical Chemistry; Physiology; Polycaprolactone; Polymer Sciences; Polymers; Scanning electron microscopy; Skin; Soft and Granular Matter; Software; Spectrum analysis; Tissue engineering; United States > US; Japan; India; Porous PCL (PPCL); Electrospun Mats; Porous Fiber; Simulated Wound Fluid (SWF); Subsequent Alkali Treatment
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-018-2442-7

A simplified method to modify electrospun PCL fibers for better degradation and cytocompatibility is proposed. The surface modification was achieved by preparing fibers having pores and subsequent alkali treatment. The modifications were studied by comparing hydrolyzed PCL mats, porous PCL mats and hydrolyzed porous PCL mats with unmodified PCL mats. The in vitro degradation analyzed in simulated wound fluid and biological response using L-929 cells confirmed surface-hydrolyzed porous PCL fibers as non-cytotoxic with enhanced cell adhesion, viability and degradability. The proposed modification will be suitable to fabricate implantable electrospun scaffolds.