Synthesis of new acridine-9-carboxylic acid derivatives
New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesize...
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| Published in | Russian chemical bulletin Vol. 67; no. 5; pp. 878 - 883 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.05.2018
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds. |
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| AbstractList | New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds. |
| Author | Kobrakov, K. I. Kuznetsov, D. N. Melyshenkova, V. V. Ruchkina, A. G. |
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| Keywords | methylphloroglucinol Pfitzinger reaction azo-coupling isatin 1,3-dihydroxy-2-methylacridine- 9-carboxylic acids bromination |
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| SubjectTerms | Bromination Carboxylic acids Chemical reactions Chemistry Chemistry and Materials Science Chemistry/Food Science Computer simulation Full Articles Inorganic Chemistry Organic Chemistry Pharmacology |
| Title | Synthesis of new acridine-9-carboxylic acid derivatives |
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