Synthesis of new acridine-9-carboxylic acid derivatives
New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesize...
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Published in | Russian chemical bulletin Vol. 67; no. 5; pp. 878 - 883 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.05.2018
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-018-2152-1 |