Synthesis of new acridine-9-carboxylic acid derivatives

New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesize...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 67; no. 5; pp. 878 - 883
Main Authors Melyshenkova, V. V., Kuznetsov, D. N., Ruchkina, A. G., Kobrakov, K. I.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2018
Springer Nature B.V
Subjects
Bromination
Carboxylic acids
Chemical reactions
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Computer simulation
Full Articles
Inorganic Chemistry
Organic Chemistry
Pharmacology
methylphloroglucinol
Pfitzinger reaction
azo-coupling
isatin
1,3-dihydroxy-2-methylacridine- 9-carboxylic acids
bromination
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Summary:New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2152-1