Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery

A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 68; no. 5; pp. 1096 - 1101
Main Authors Korolev, D. V., Evreinova, N. V., Zakharova, E. V., Gareev, K. G., Naumysheva, E. B., Postnov, D. V., Postnov, V. N., Galagudza, M. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2019
Springer Nature B.V
Subjects
Chemisorption
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug delivery systems
Full Article
Immobilization
Inorganic Chemistry
Magnetite
Nanoparticles
Organic Chemistry
Silicon dioxide
magnetite nanoparticles
amination
immobilization
phosphocreatine
silica nanoparticles
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Summary:A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-019-2525-0