Synthesis of substituted pyrido[3´,2´:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones and their sulfinyl and sulfonyl derivatives
A method for the synthesis of previously unknown pyrido[3´,2´:4,5]thieno[3,2- c ]isoquinolin-5(6 H )-ones was suggested, which includes a condensation reaction of substituted 3-cyanopyridine-2(1 H )-thiones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation products wi...
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Published in | Russian chemical bulletin Vol. 66; no. 3; pp. 523 - 530 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.03.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A method for the synthesis of previously unknown pyrido[3´,2´:4,5]thieno[3,2-
c
]isoquinolin-5(6
H
)-ones was suggested, which includes a condensation reaction of substituted 3-cyanopyridine-2(1
H
)-thiones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation products with potassium
tert
-butoxide. The oxidation of the condensation products to sulfoxides or sulfones and subsequent treatment of these compounds with potassium
tert
-butoxide led to substituted pyrido[3´,2´:4,5]thieno[3,2-
c
]isoquinolin-5(6
H
)-one 11-oxides or substituted pyrido[3´,2´:4,5]thieno[3,2-
c
]isoquinolin-5(6
H
)-one 11,11-dioxides. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-017-1766-z |