Microsatellite polymorphism in intron 1 of the bovine myostatin gene

Microsatellites within genes have become important because of their association with genetic diseases in humans. A novel microsatellite was identified in the first intron of the bovine myostatin gene. It is characterized by a mononucleotide core motif that exhibits polymorphic sequence variants (fro...

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Bibliographic Details
Published inJournal of applied genetics Vol. 47; no. 1; pp. 55 - 57
Main Authors De la Rosa-Reyna, Xochitl F, Rodríguez Pérez, Mario A, Sifuentes-Rincón, Ana M
Format Journal Article
LanguageEnglish
Published England 01.01.2006
Subjects
Animals
Artiodactyla
Base Sequence
Cattle - classification
Cattle - genetics
Genotype
Introns - genetics
Microsatellite Repeats - genetics
Molecular Sequence Data
Myostatin
Phylogeny
Polymerase Chain Reaction
Transforming Growth Factor beta - genetics
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Summary:Microsatellites within genes have become important because of their association with genetic diseases in humans. A novel microsatellite was identified in the first intron of the bovine myostatin gene. It is characterized by a mononucleotide core motif that exhibits polymorphic sequence variants (from 12 to 21 repeats) within and between some bovine breeds. Structural analysis of the microsatellite region in bovines as well as in closely related species permitted to trace the possible mechanisms for its structural evolution across the order Artiodactyla.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1234-1983
2190-3883
DOI:10.1007/BF03194599