Micronization of Levofloxacin Using the RESS Method

The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF micro...

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Bibliographic Details
Published inRussian journal of physical chemistry. B Vol. 14; no. 7; pp. 1225 - 1228
Main Authors Antonov, E. N., Krotova, L. I., Mishakov, G. V., Popov, V. K.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2020
Springer Nature B.V
Subjects
Antiinfectives and antibacterials
Bioavailability
Carbon dioxide
Chemistry
Chemistry and Materials Science
Ethanol
Microparticles
Physical Chemistry
antibacterial drugs
RESS
levofloxacin
superficial fluid technologies
micronization
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Summary:The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with the characteristic size of <10 microns are obtained.
ISSN:1990-7931
1990-7923
DOI:10.1134/S1990793120070210