Radiobiological considerations in the use of total-body irradiation for bone-marrow transplantation

On radiobiological grounds, a therapeutic advantage should result when total body irradiation (TBI) in preparation for bone-marrow engraftment is given as a fractionated course, rather than as a single exposure at logistically reasonable dose rates. This is because cells of hemopoietic origin in gen...

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Bibliographic Details
Published inRadiology Vol. 131; no. 1; p. 243
Main Authors Peters, L J, Withers, H R, Cundiff, J H, Dicke, K A
Format Journal Article
LanguageEnglish
Published United States 01.04.1979
Subjects
Animals
Bone Marrow - radiation effects
Bone Marrow Cells
Bone Marrow Transplantation
Hematopoietic Stem Cells - radiation effects
Humans
Leukemia - radiotherapy
Lung - radiation effects
Mice
Radiation Injuries
Radiotherapy - instrumentation
Radiotherapy Dosage
Transplantation, Homologous
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Summary:On radiobiological grounds, a therapeutic advantage should result when total body irradiation (TBI) in preparation for bone-marrow engraftment is given as a fractionated course, rather than as a single exposure at logistically reasonable dose rates. This is because cells of hemopoietic origin in general show less capacity for repair of sublethal radiation injury than do cells of other organs. Dose-limiting lung tolerance, in the context of fractionated TBI, is estimated to be at least 12 Gy (without correction) in increments of 2 Gy regardless of dose rate. A practical method for delivering TBI using a high-energy linear accelerator is described.
ISSN:0033-8419
DOI:10.1148/131.1.243