Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid

• Published in: Journal of solid state electrochemistry Vol. 21; no. 4; pp. 1089 - 1099
• Main Authors: Spindola, Rolff Ferreira, Zanin, Hudson, Macena, Cleidivan Silva, Contin, André, de Cássia Silva Luz, Rita, Damos, Flávio Santos
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2017; Springer Nature B.V
• Subjects: Analytical Chemistry; Biocompatibility; Biomedical materials; Body fluids; Carbon; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; Electrical measurement; Electrochemical impedance spectroscopy; Electrochemistry; Electrodes; Electrolytic analysis; Energy Storage; Glassy carbon; Graphene; In vitro methods and tests; Iron; Metal phthalocyanines; Multi wall carbon nanotubes; Original Paper; Oxidation; Physical Chemistry; Silver chloride; Surgical implants; Multi-walled carbon nanotube oxide; Graphene oxide; Isoniazid; Iron phthalocyanine
• ISSN: 1432-8488; 1433-0768
• DOI: 10.1007/s10008-016-3451-9

A novel platform for electroanalysis of isoniazid based on graphene-functionalized multi-walled carbon nanotube as support for iron phthalocyanine (FePc/f - MWCNT) has been developed. The FePc/f - MWCNT composite has been dropped on glassy carbon forming FePc/f - MWCNT/GC electrode, which is sensible for isoniazid, decreasing substantially its oxidation potential to +200 mV vs Ag/AgCl. Electrochemical and electroanalytical properties of the FePc/f - MWCNT/GC-modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, and amperometry. The sensor presents better performance in 0.1 mol L −1 phosphate buffer at pH 7.4. Under optimized conditions, a linear response range from 5 to 476 μmol L −1 was obtained with a limit of detection and sensitivity of 0.56 μmol L −1 and 0.023 μA L μmol −1 , respectively. The relative standard deviation for 10 determinations of 100 μmol L −1 isoniazid was 2.5%. The sensor was successfully applied for isoniazid selective determination in simulated body fluids.