Progress in cancer therapy with functionalized Fe3O4 nanomaterials

• Published in: Frontiers of materials science Vol. 17; no. 3
• Main Authors: Wang, Yuhui, Liu, Xuanyu, Ma, Shilong, He, Xuhong, Guo, Chaiqiong, Liang, Ziwei, Hu, Yinchun, Wei, Yan, Lian, Xiaojie, Huang, Di
• Format: Journal Article
• Language: English
• Published: Beijing Higher Education Press 01.09.2023; Springer Nature B.V
• Subjects: Biocompatibility; Biomedical materials; Cancer; Chemistry and Materials Science; Diagnosis; Hyperthermia; Iron oxides; Magnetic properties; Materials Science; Nanomaterials; Nanoparticles; Neoplasms; Pharmacology; Public health; Review Article; NPs; cancer treatment; magnetic targeting; Fe; O; magnetic thermotherapy
• ISSN: 2095-025X; 2095-0268
• DOI: 10.1007/s11706-023-0658-4

Malignant neoplasms represent a significant global health threat. To address the need for accurate diagnosis and effective treatment, research is underway to develop therapeutic nanoplatforms. Iron oxide nanoparticles (NPs), specifically Fe 3 O 4 NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting, favorable biocompatibility, high magnetic response sensitivity, prolonged in vivo circulation time, stable performance, and high self-metabolism. Their ability to be integrated with magnetic hyperthermia, photodynamic therapy, and photothermal therapy has resulted in the widespread use of Fe 3 O 4 NPs in cancer diagnosis and treatment, making them a popular choice for such applications. Various methods can be employed to synthesize magnetic Fe 3 O 4 NPs, which can then be surface-modified with biocompatible materials or active targeting molecules. Multifunctional systems can be created by combining Fe 3 O 4 NPs with polymers. By combining various therapeutic approaches, more effective biomedical materials can be developed. This paper discusses the synthesis of Fe 3 O 4 NPs and the latest research advances in Fe 3 O 4 -based nanotherapeutic platforms, as well as their applications in the biomedical field.