Conjugates of 3,4-dimethoxy-4-styrylnaphthalimide and bacteriochlorin for theranostics in photodynamic therapy

New conjugates of fluorophore based on 3,4-dimethoxy-4-styryl-1,8-naphthalimide and photosensitizer bacteriochlorin e differing in the nature of spacer fragments were synthesized and their spectral-luminescent properties were studied. The conjugates efficiently generate singlet oxygen in solution, h...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 69; no. 6; pp. 1169 - 1178
Main Authors Zakharko, M. A., Panchenko, P. A., Zarezin, D. P., Nenajdenko, V. G., Pritmov, D. A., Grin, M. A., Mironov, A. F., Fedorova, O. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2020
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Conjugates
Energy transfer
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Inorganic Chemistry
Optical properties
Organic Chemistry
Photodynamic therapy
Photoexcitation
Singlet oxygen
singlet oxygen generation
conjugate
fluorescence
styryl dyes
energy transfer
theranostics
1,8-naphthalimide
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Summary:New conjugates of fluorophore based on 3,4-dimethoxy-4-styryl-1,8-naphthalimide and photosensitizer bacteriochlorin e differing in the nature of spacer fragments were synthesized and their spectral-luminescent properties were studied. The conjugates efficiently generate singlet oxygen in solution, however, the emission of the naphthalimide fragment of the conjugates is quenched to varying degrees as a result of the photoexcitation energy transfer to bacteriochlorin.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2885-5