Synthesis, Crystal Structure, and Biological Activity of α-Hydroxyphosphonates

A series of dialkyl [aryl(hydroxy)methyl]phosphonates with various substituents at the phosphorus atom was obtained by the Abramov reaction. The structure of the isolated products was confirmed by IR and NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. All the obtained compounds...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 59; no. 8; pp. 1342 - 1347
Main Authors Sedov, A. N., Davletshin, R. R., Davletshina, N. V., Ivshin, K. A., Fedonin, A. P., Osogostok, A. R., Shulaeva, M. P.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.08.2023
Springer Nature
Springer Nature B.V
Subjects
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Crystal structure
Infrared spectroscopy
Mass spectrometry
NMR spectroscopy
Organic Chemistry
Phosphonates
Physical Sciences
Science & Technology
biological activity
Abramov reaction
α-hydroxyphosphonate
X-ray diffraction analysis
alpha-hydroxyphosphonate
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Summary:A series of dialkyl [aryl(hydroxy)methyl]phosphonates with various substituents at the phosphorus atom was obtained by the Abramov reaction. The structure of the isolated products was confirmed by IR and NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. All the obtained compounds demonstrated activity against B. cereus and S. aureus bacterial strains.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023080080