The feasibility of low-dose CT perfusion imaging in gastric cancer

• Published in: Journal of X-ray science and technology Vol. 25; no. 5; pp. 847 - 855
• Main Authors: Sun, Zong-Qiong, Ge, Yu-Xi, Chen, Lin, Li, Jie, Jin, Lin-Fang, Xie, Zhi-Hui
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2017
• Subjects: Adult; Aged; Feasibility Studies; Female; Humans; Male; Middle Aged; Perfusion Imaging - methods; Stomach Neoplasms - diagnostic imaging; Tomography, X-Ray Computed - methods; Low-dose; computed tomography; perfusion imaging; gastric cancer
• ISSN: 0895-3996; 1095-9114
• DOI: 10.3233/XST-17282

PURPOSE: To investigate feasibility of applying low-dose CT perfusion imaging (CTPI) to diagnose gastric cancer. MATERIALS AND METHODS: Twenty patients with gastric cancer confirmed by endoscopic biopsy were undergone routine dose (120 kV, 100 mA) and low-dose (120 kV, 50 mA) CTPI examination, respectively. The original data were processed by body perfusion software, and the perfusion parameters values including blood flow (BF), blood volume (BV) and permeability surface (PS) of gastric cancer were measured. Statistical data analyses including paired-samples t test, Pearson correlation analysis and Bland-Altman consistency test were used to compare the perfusion parameters values between the routine dose and low-dose CTPI examinations. Radiation dosage, which the patients received during two CTPI examinations, was also calculated and compared. RESULTS: There were no statistical differences in the BF, BV and PS values between routine dose group and low-dose group (P > 0.05), and there were significant correlation in the BF, BV and PS values between two groups (P <  0.01). The consistency of BF and BV values between the two groups was preferable to that of PS value. The radiation dosage of the low-dose group was much less than that of routine dose group, and the CTDIvol and DLP values of low-dose CTPI were decreased by 50%, respectively. CONCLUSION: The parameters BF and BV values may play a valuable role in the diagnosis and assessment of gastric cancer in low-dose CTPI examination.