Synthesis and antiproliferative properties of 3,4-diarylpyrrole-2-carboxamides
A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.
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Published in | Russian chemical bulletin Vol. 70; no. 3; pp. 498 - 509 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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01.03.2021
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Abstract | A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines. |
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AbstractList | A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines. |
Author | Semenova, M. N. Semenov, V. V. Samet, A. V. Silyanova, E. A. |
Author_xml | – sequence: 1 givenname: E. A. surname: Silyanova fullname: Silyanova, E. A. email: cea93@mail.ru organization: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences – sequence: 2 givenname: A. V. surname: Samet fullname: Samet, A. V. organization: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences – sequence: 3 givenname: M. N. surname: Semenova fullname: Semenova, M. N. organization: N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences – sequence: 4 givenname: V. V. surname: Semenov fullname: Semenov, V. V. organization: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences |
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Cites_doi | 10.1016/j.ejmech.2009.09.017 10.1007/s10593-011-0701-8 10.1021/cr078199m 10.1016/j.tet.2017.10.016 10.1007/s11172-018-2150-3 10.2144/000112193 10.1070/RCR4449 10.1021/acs.orglett.9b01830 10.1002/asia.201500611 10.1007/s11172-018-2375-1 10.3390/md12126142 10.1002/ejoc.202000099 10.1016/j.mencom.2019.03.015 10.1021/jm00010a011 10.1016/B978-0-444-64183-0.00012-9 10.3987/REV-10-686 10.1021/cb700163q 10.1021/acscombsci.8b00113 10.1016/j.bmcl.2016.05.026 10.1021/jacs.7b04564 10.1002/asia.201000237 10.1021/np1004278 10.1016/j.bmc.2006.02.018 10.1039/C1MD00003A 10.1021/acscombsci.9b00135 10.1016/j.gde.2013.04.010 |
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Keywords | 3,4-diarylpyrrole-2-carboxamides tubulin sea urchin embryo nitrostilbenes Barton—Zard reaction antiproliferative activity |
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Title | Synthesis and antiproliferative properties of 3,4-diarylpyrrole-2-carboxamides |
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