Synthesis and antiproliferative properties of 3,4-diarylpyrrole-2-carboxamides

A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.

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Published inRussian chemical bulletin Vol. 70; no. 3; pp. 498 - 509
Main Authors Silyanova, E. A., Samet, A. V., Semenova, M. N., Semenov, V. V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2021
Springer Nature B.V
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Abstract A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.
AbstractList A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.
Author Semenova, M. N.
Semenov, V. V.
Samet, A. V.
Silyanova, E. A.
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Issue 3
Keywords 3,4-diarylpyrrole-2-carboxamides
tubulin
sea urchin embryo
nitrostilbenes
Barton—Zard reaction
antiproliferative activity
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Snippet A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The...
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SubjectTerms Antiproliferatives
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Embryos
Full Articles
Inorganic Chemistry
Organic Chemistry
Title Synthesis and antiproliferative properties of 3,4-diarylpyrrole-2-carboxamides
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