Synthesis and antiproliferative properties of 3,4-diarylpyrrole-2-carboxamides

A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.

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Bibliographic Details
Published inRussian chemical bulletin Vol. 70; no. 3; pp. 498 - 509
Main Authors Silyanova, E. A., Samet, A. V., Semenova, M. N., Semenov, V. V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2021
Springer Nature B.V
Subjects
Antiproliferatives
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Embryos
Full Articles
Inorganic Chemistry
Organic Chemistry
3,4-diarylpyrrole-2-carboxamides
tubulin
sea urchin embryo
nitrostilbenes
Barton—Zard reaction
antiproliferative activity
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Summary:A series of 3,4-diarylpyrrole-2-carboxamides was synthesized using the Barton—Zard reaction of nitrostilbenes with ethyl isocyanoacetate in the key stage. The antiproliferative properties of these compounds were studied on a sea urchin embryo model, as well as on 60 human tumor cell lines.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3115-5