Yadanziolide A Inhibits Proliferation and Induces Apoptosis of Hepatocellular Carcinoma via JAK-STAT Pathway: A Preclinical Study

• Published in: Biology (Basel, Switzerland) Vol. 13; no. 7; p. 528
• Main Authors: Lin, Lili, Chen, Qi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.07.2024
• Subjects: Animal models; Antibodies; Antitumor activity; Apoptosis; Cancer therapies; Cell culture; Cell death; Cell migration; Cell proliferation; Cell survival; Chinese medicine; Cytotoxicity; Flow cytometry; Hepatocellular carcinoma; Hepatocytes; Janus kinase 2; Liver cancer; Medical innovations; Medical prognosis; Morphology; Phosphorylation; Population studies; proliferation; Public health; Stat3 protein; the JAK-STAT pathway; Tumor necrosis factor-α; Tumors; Yadanziolide A; United States > US; apoptosis; the JAK-STAT pathway; proliferation; hepatocellular carcinoma; Yadanziolide A
• ISSN: 2079-7737; 2079-7737
• DOI: 10.3390/biology13070528

Liver cancer is a significant global health concern, prompting the search for innovative therapeutic solutions. ( ), a natural derivative of Brucea javanica, has emerged as a promising candidate for cancer treatment; however, its efficacy and underlying mechanisms in liver cancer remain incompletely understood. In this study, we conducted a comprehensive evaluation of s effects on liver cancer cells using a range of in vitro assays and an orthotopic liver cancer mouse model. Our findings reveal that exerts dose-dependent cytotoxic effects on liver cancer cells, significantly inhibiting proliferation, migration, and invasion at concentrations ≥ 0.1 μM. Furthermore, induces apoptosis, as evidenced by increased apoptotic cell populations and apoptosome formation. In vivo studies confirm that inhibits tumor growth and reduces liver damage in mouse models. Mechanistically, targets the TNF-α/STAT3 pathway, inhibiting STAT3 and JAK2 phosphorylation, thereby activating apoptotic pathways and suppressing tumor cell growth. These results suggest that has promising anticancer activity and potential utility in liver cancer therapy.