Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9βh)-3β-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)

• Published in: Medicinal chemistry research Vol. 25; no. 10; pp. 2250 - 2257
• Main Authors: Oke-Altuntas, Feyza, Kapche, Gilbert D.W. F., Nantchouang Ouete, Judith L., Demirtas, Ibrahim, Koc, Merve B., Ngadjui, Bonaventure T.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2016; Springer Nature B.V
• Subjects: Antimicrobial activity; Antioxidants; Bark; Biochemistry; Biological activity; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cervix; Cytotoxicity; Methanol; Original Research; Pharmacology/Toxicology; Tumor cell lines; HeLa; Cytotoxic effect; Cudraxanthone I; Antioxidant activity; Neocyclomorusin
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-016-1670-3

This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1) , neocyclomorusin (2) and (9 β H)-3 β -acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC 50  < 10 µg/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC 50  = 0.73 ± 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.