Production of proteinases with fibrinolytic and fibrinogenolytic activity by a micromycete Aspergillus ochraceus

Fibrinolytic and fibrinogenolytic activity of surface and submerged cultures of a micromycete Aspergillus ochraceus L-1 was studied. Extracellular proteinases produced by A. ochraceus L-1 were found to exhibit specificity against fibrin and fibrinogen and no activity of plasminogen activators. The h...

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Published inMicrobiology (New York) Vol. 86; no. 4; pp. 512 - 516
Main Authors Osmolovskiy, A. A., Rukavitsyna, E. D., Kreier, V. G., Baranova, N. A., Egorov, N. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2017
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Experimental Articles
Fibrin
Fibrinogen
Life Sciences
Medical Microbiology
Microbiology
pH effects
Plasmin
fibrinogenolytic activity
micromycetes proteinases
enzymatic index
fibrinolytic enzymes
Aspergillus proteinases
fibrinolytic activity
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Summary:Fibrinolytic and fibrinogenolytic activity of surface and submerged cultures of a micromycete Aspergillus ochraceus L-1 was studied. Extracellular proteinases produced by A. ochraceus L-1 were found to exhibit specificity against fibrin and fibrinogen and no activity of plasminogen activators. The highest activity was observed in the cultures grown at 28°С and initial pH 7.0. Fibrinolytic activity was shown to be somewhat above 25% of the total plasmin-like activity of A. ochraceus L-1 proteinases.
ISSN:0026-2617
1608-3237
DOI:10.1134/S0026261717040105