Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity

This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H 2 O)X 2 ] (X = Cl, Br, I) and [Cu(caf) 2 Br 2 ] (1). The cytotoxicity of the complexes is dose-dependent...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 69; no. 7; pp. 1394 - 1400
Main Authors Rukk, N. S., Kuzmina, L. G., Davydova, G. A., Buzanov, G. A., Belus, S. K., Kozhukhova, E. I., Retivov, V. M., Ivanova, T. V., Krasnoperova, V. N., Bolotin, B. M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2020
Springer Nature B.V
Subjects
Biological activity
Biological properties
Caffeine
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Coordination compounds
Copper bromide
Copper compounds
Cytotoxicity
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Inorganic Chemistry
Organic Chemistry
Stem cells
Structural analysis
Toxicity
Zinc
zinc(II) halides
caffeine
square-planar structure
copper(II) bromide
molecular complex
cytotoxicity
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Summary:This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H 2 O)X 2 ] (X = Cl, Br, I) and [Cu(caf) 2 Br 2 ] (1). The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2914-4