Boron doped graphdiyne: A metal-free peroxidase mimetic nanozyme for antibacterial application

• Published in: Nano research Vol. 15; no. 2; pp. 1446 - 1454
• Main Authors: Bi, Xuelong, Bai, Qiang, Wang, Lina, Du, Fanglin, Liu, Manhong, Yu, William W., Li, Siheng, Li, Jiaqiang, Zhu, Zhiling, Sui, Ning, Zhang, Jin
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 01.02.2022; Springer Nature B.V
• Subjects: Abuse; Allotropy; Antibiotics; Antiinfectives and antibacterials; Atomic/Molecular Structure and Spectra; Bacteria; Biocompatibility; Biomedicine; Biotechnology; Boron; Catalytic activity; Chemistry and Materials Science; Condensed Matter Physics; Decomposition; Decomposition reactions; Density functional theory; Free energy; Gibbs free energy; Gram-negative bacteria; Gram-positive bacteria; Hydrogen peroxide; Materials Science; Nanomaterials; Nanotechnology; Peroxidase; Physicochemical properties; Reactive oxygen species; Research Article; Wound healing; graphdiyne; wound healing; antibacterial; nanozyme; metal-free
• ISSN: 1998-0124; 1998-0000
• DOI: 10.1007/s12274-021-3685-4

The abuse of conventional antibiotics leads to increasing bacterial resistance. Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities, showing remarkable potential as a next generation nanobactericide. Graphdiyne (GDY) is a burgeoning two-dimensional (2D) carbon allotrope with intriguing physicochemical properties, holding a great promise as a metal-free nanozyme. In this study, a boron doped GDY nanosheet (B-GDY) was constructed to simulate the performance of peroxidase (POD). By promoting the decomposition of H 2 O 2 to produce reactive oxygen species (ROS), the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY. In-depth density functional theory (DFT) calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H 2 O 2 decomposition reaction. Notably, B-GDY contributes to significant wound healing and excellent biocompatibility, reducing the biological burden. The design of this nanozyme opens a new avenue for the development of alternative antibiotics.