Synthesis of Novel 2-(N-Substituted)imino-2,5-dihydrofuran-3-carboxamides Containing a Thiourea Residue and an Oxothiazolidinylidene Ring

Novel derivatives of 2-imino-2,5-dihydrofuran-3-carboxamides containing a thiourea residue have been synthesized by the reaction of 2-imino-2,5-dihydrofuran-3-carboxamides with thiosemicarbazide in glacial acetic acid. The synthesized N -substituted iminodihydrofurans have been condensed with ethyl...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 55; no. 11; pp. 1806 - 1808
Main Authors Karapetyan, L. V., Tokmajyan, G. G., Makaryan, G. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2019
Springer Nature
Springer Nature B.V
Subjects
Acetic acid
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Derivatives
Organic Chemistry
Physical Sciences
Science & Technology
Short Communications
Substitutes
Thioureas
thiourea residue
aromatic substituent
oxothiazolidinylidene ring
2-imino-2,5-dihydrofuran-3-carboxamide
substituted iminodihydrofurans
thiosemicarbazide
thiourea
CHEMICAL-TRANSFORMATIONS
residue N-substituted iminodihydrofurans
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Summary:Novel derivatives of 2-imino-2,5-dihydrofuran-3-carboxamides containing a thiourea residue have been synthesized by the reaction of 2-imino-2,5-dihydrofuran-3-carboxamides with thiosemicarbazide in glacial acetic acid. The synthesized N -substituted iminodihydrofurans have been condensed with ethyl chloroacetate to obtain novel derivatives of iminodihydrofurans containing an oxothiazolidinylidene ring. These methods open up new synthetic approaches to previously unknown systems containing iminodihydrofuran, thiourea and oxothiazolidinylidene fragments.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019110265