Abscopal effect of irradiation on haemopoietic stem cells of shielded bone marrow--role of migration

Immediately after partial-body irradiation, the number of colony-forming units (CFU) of the protected marrow decreases. This decrease seems to be dose-dependent and cannot be completely explained by migration for the following reasons: there is no evidence of CFU entry to irradiated territories and...

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Bibliographic Details
Published inInternational journal of radiation biology and related studies in physics, chemistry and medicine Vol. 30; no. 4; p. 347
Main Authors Croizat, H, Frindel, E, Tubiana, M
Format Journal Article
LanguageEnglish
Published England 1976
Subjects
Animals
Bone Marrow - physiopathology
Cell Movement
Cobalt Radioisotopes
Dose-Response Relationship, Radiation
Elementary Particles
Female
Hematopoietic Stem Cells - physiopathology
Mice
Mice, Inbred C3H
Radiation Injuries, Experimental - physiopathology
Spleen - physiopathology
X-Rays
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Summary:Immediately after partial-body irradiation, the number of colony-forming units (CFU) of the protected marrow decreases. This decrease seems to be dose-dependent and cannot be completely explained by migration for the following reasons: there is no evidence of CFU entry to irradiated territories and the number of circulating CFU does not increase. A more plausible explanation for the phenomena is an accelerated differentiation during the first 15 min after irradiation. The migration of CFU to the spleen is observed between 15 min and 3 hours after irradiation, after which it ceases. The absence of migration 3 hours after irradiation may be due to one of the two possibilities: (1) a depletion of the mobile pool of CFU if one admits that such a pool is responsible for migration in the organism; (2) a depletion of a temporarily increased stimulus due to irradiation.
ISSN:0020-7616
DOI:10.1080/09553007614551121