2D Porous Aromatic Framework as a Novel Solid-Phase Extraction Adsorbent for the Determination of Trace BPA in Milk

• Published in: Chromatographia Vol. 81; no. 5; pp. 749 - 758
• Main Authors: Yin, Dan, Chen, Yanlong, Zhang, Yanhao, Yang, Zhicong, Mao, Hongyan, Xia, Shaige, Zhang, Wenfen, Zhao, Wuduo, Zhang, Shusheng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2018; Springer Nature B.V
• Subjects: Analytical Chemistry; Cartridges; Chemical bonds; Chemistry; Chemistry and Materials Science; Chromatography; Fluorescence; High performance liquid chromatography; Hydrogen bonding; Laboratory Medicine; Milk; Original; Pharmacy; Proteomics; Porous aromatic framework; Bisphenol A; HPLC; Solid-phase extraction; Milk
• ISSN: 0009-5893; 1612-1112
• DOI: 10.1007/s10337-018-3504-6

A rapid and effective solid-phase extraction high-performance liquid chromatography fluorescence detection (SPE-HPLC–FLD) method, using a novel porous aromatic framework (PAF-6) as solid-phase extraction sorbent, was established to enrich and determine bisphenol (BPA) in milk and its packing samples. Parameters influencing the extraction efficiency, such as volume of the sample solutions, pH of the sample, and the eluent volume, were examined. The limits of detection and quantitation were 0.1 and 0.33 ng mL −1 , respectively. The recovery of the method was desirable at 81–91% and the relative standard deviation was less than 2.35%. Besides, the PAF-6-based cartridges exhibited superior reusability for milk sample analysis. In addition, theoretical computations were performed to further understand the molecular interaction mechanism between the PAF-6 and the BPA. The results showed that PAF-6 had an excellent adsorption capability for BPA based on hydrogen bonding and the inclusion interactions of host–guest. The proposed method is sensitive, simple, and cost-saving, and provides a detection platform for the monitoring of BPA residues in real milk samples. Graphical Abstract