Construction of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as a potential antibacterial agents

A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against...

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Published inResearch on chemical intermediates Vol. 42; no. 12; pp. 8157 - 8174
Main Authors El-Essawy, Farag A., Boshta, Nader M., Alotaibi, Mshari A., Elsayed, Mohamed S., Tarabees, Reda, Saleh, Ebtsam A.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2016
Springer Nature
Springer Nature B.V
Subjects
Antiinfectives and antibacterials
Catalysis
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Inorganic Chemistry
NMR
Nuclear magnetic resonance
Physical Chemistry
Physical Sciences
Science & Technology
Synthesis
Antimicrobial
Quinolone
Synthesis
4-Oxo-1,4-dihydroquinolines
DESIGN
ANTIMICROBIALS
QUINOLONES
INHIBITORS
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Summary:A novel series of 1,3-disubstituted 4-oxo-1,4-dihydroquinolines as antimicrobial agents were designed and synthesized. Their structures have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Most of the newly prepared compounds were screened for their antimicrobial activities against two Gram-positive bacterial strains and six Gram-negative bacterial strains. Many of the synthesized compounds displayed a high antimicrobial activity in comparison with reference drugs, for example compounds 4 – 6 , 15 , 17 , and 18 .
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-016-2586-8