Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy

Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl- sn -glycero-3-phosphoethanolamine) served for the preparation of cationi...

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Published inRussian journal of bioorganic chemistry Vol. 43; no. 5; pp. 561 - 569
Main Authors Puchkov, P. A., Perevoshchikova, K. A., Kartashova, I. A., Luneva, A. S., Kabilova, T. O., Morozova, N. G., Zenkova, M. A., Maslov, M. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2017
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cations
Cholesterol
Life Sciences
Liposomes
Organic Chemistry
Toxicity
triethylenetetramine
nucleic acid delivery
polycationic amphiphiles
cationic liposomes
transfection
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Summary:Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl- sn -glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162017050107