Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer

• Published in: Chemical research in Chinese universities Vol. 38; no. 2; pp. 562 - 571
• Main Authors: Wu, Liting, Xin, Yujia, Guo, Zhaoyang, Gao, Wei, Zhu, Yanpeng, Wang, Yinsong, Ran, Ruixue, Yang, Xiaoying
• Format: Journal Article
• Language: English
• Published: Changchun Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01.04.2022; Springer Nature B.V
• Subjects: Analytical Chemistry; Anticancer properties; Cell membranes; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Copper sulfides; Erythrocytes; Hypoxia; Inorganic Chemistry; Nanoparticles; Organic Chemistry; Oxygen; Physical Chemistry; Radiation therapy; Silicon dioxide; Photothermal therapy; Dendritic large pore mesoporous silica nanoparticle; Radiosensitization; Oxygen carrying; Red blood cell membrane
• ISSN: 1005-9040; 2210-3171
• DOI: 10.1007/s40242-021-1068-8

C ombining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT.