The influence of barbiturates on cerebral metabolism in patients with borderline cerebrovascular reserve during intraoperative transient carotid occlusion

Sixty patients with borderline or frank insufficiency of their cerebrovascular reserve undergoing carotid endarterectomy were given enough short acting barbiturates, during cross clamping of the internal carotid artery, to cause EEG burst suppression. Arterial and venous concentrations of lactate we...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of neurosurgery Vol. 3; no. 4; p. 429
Main Authors Wassman, H, Fromm, G, Nadstawek, J, Bannister, C, Hartmann, A, Pavlidis, C
Format Journal Article
LanguageEnglish
Published England 1989
Subjects
Barbiturates - therapeutic use
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Brain Ischemia - physiopathology
Cerebrovascular Disorders - surgery
Electroencephalography
Endarterectomy - adverse effects
Female
Humans
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:Sixty patients with borderline or frank insufficiency of their cerebrovascular reserve undergoing carotid endarterectomy were given enough short acting barbiturates, during cross clamping of the internal carotid artery, to cause EEG burst suppression. Arterial and venous concentrations of lactate were measured in blood samples taken before, 30 min after occlusion of the artery and 10 min after reperfusion. The amount of lactate produced depended on the length of time of burst suppression; the shorter it lasted, the larger the amount of lactate produced. Only in patients with the shortest burst suppression times did the blood lactate levels rise above normal levels. The lactate levels can be used as indicators of how effective barbiturates are being in preventing ischaemia during the time of carotid artery occlusion.
ISSN:0268-8697
DOI:10.3109/02688698909002828