Sterically Hindered Phenolic Isatin Derivatives Containing a DABCO Fragment: Synthesis and Antimicrobial Activity Testing

The condensation of phenolic isatin derivatives with 1-(2-hydrazinyl-2-oxoethyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide yielded a series of isatin-3-acylhydrazones containing a monocationic DABCO fragment. New compounds have antimicrobial activity against phytopathogenic bacteria and fungi, as w...

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Published inRussian journal of organic chemistry Vol. 58; no. 8; pp. 1067 - 1075
Main Authors Bogdanov, A. V., Voloshina, A. D., Lyubina, A. P., Amerkhanova, S. K., Glukhareva, T. V., Mironov, V. F.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.08.2022
Springer Nature
Springer Nature B.V
Subjects
Antiinfectives and antibacterials
Bacteria
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Fungi
Organic Chemistry
Physical Sciences
Science & Technology
antimicrobial activity
phytopathogens
isatin
DABCO
antifungal activity
hydrazones
IONIC LIQUID
CATALYSTS
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Summary:The condensation of phenolic isatin derivatives with 1-(2-hydrazinyl-2-oxoethyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide yielded a series of isatin-3-acylhydrazones containing a monocationic DABCO fragment. New compounds have antimicrobial activity against phytopathogenic bacteria and fungi, as well as a number of anthropopathogenic bacteria and fungi. Salts based on 5-alkylisatins exhibit bactericidal effect against Staphylococcus aureus at a concentration of 15.6 μg/mL.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022080012