No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the co...

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Bibliographic Details
Published inNeurology Vol. 53; no. 2; p. 418
Main Authors MacLeod, M J, Dahiyat, M T, Cumming, A, Meiklejohn, D, Shaw, D, St Clair, D
Format Journal Article
LanguageEnglish
Published United States 22.07.1999
Subjects
Aged
Alleles
Aspartic Acid
Brain Ischemia - genetics
Cerebrovascular Disorders - genetics
Female
Genotype
Glutamic Acid
Humans
Male
Middle Aged
Nitric Oxide Synthase - genetics
Odds Ratio
Polymorphism, Genetic
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Summary:Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
ISSN:0028-3878
DOI:10.1212/wnl.53.2.418