Effect of Single-Injection versus Continuous Local Infiltration Analgesia after Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Study

In this randomized, double-blind, placebo-controlled, single-centre study, 80 patients (American Society of Anesthesiologists physical status I — III) received postoperative single-injection local infiltration analgesia (SLIA), continuous local infiltration analgesia (CLIA) or placebo (control group...

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Bibliographic Details
Published inJournal of international medical research Vol. 39; no. 4; pp. 1369 - 1380
Main Authors Zhang, S, Wang, F, Lu, ZD, Li, YP, Zhang, L, Jin, QH
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.08.2011
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Analgesia, Patient-Controlled
Analgesics, Opioid - administration & dosage
Anesthetics, Local - administration & dosage
Arthroplasty, Replacement, Knee
Case-Control Studies
Double-Blind Method
Female
Humans
Injections, Intravenous
Male
Middle Aged
Morphine - administration & dosage
Pain Management
Pain Measurement
Pain, Postoperative - drug therapy
Pain, Postoperative - etiology
Postoperative Care
Prognosis
Recovery of Function
Young Adult
Local infiltration analgesia
Morphine consumption
Total knee arthroplasty
Visual analogue scale
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Summary:In this randomized, double-blind, placebo-controlled, single-centre study, 80 patients (American Society of Anesthesiologists physical status I — III) received postoperative single-injection local infiltration analgesia (SLIA), continuous local infiltration analgesia (CLIA) or placebo (control group). Intravenous patient-controlled morphine was used as rescue analgesia. The CLIA group showed lower postoperative visual analogue scale (VAS) pain scores from 8 to 48 h at rest and from 16 to 48 h during activity compared with the SLIA group. The CLIA group also had significantly lower consumption of morphine from 24 to 48 h postoperatively versus the SLIA group. Patient satisfaction was higher, and maximum flexion of the knee on postoperative days 7 and 90 was greater, in the CLIA group compared with the SLIA group. CLIA provided prolonged superior analgesia and was associated with more favourable functional recovery and patient satisfaction compared with SLIA.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
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ISSN:0300-0605
1473-2300
DOI:10.1177/147323001103900423