Xymedon conjugate with biogenic acids. Antioxidant properties of a conjugate of Xymedon with l-ascorbic acid

• Published in: Russian chemical bulletin Vol. 67; no. 4; pp. 705 - 711
• Main Authors: Vyshtakalyuk, A. B., Semenov, V. E., Sudakov, I. A., Bushmeleva, K. N., Gumarova, L. F., Parfenov, A. A., Nazarov, N. G., Galyametdinova, I. V., Zobov, V. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2018; Springer Nature B.V
• Subjects: Acids; Antioxidants; Ascorbic acid; Carbon tetrachloride; Chemiluminescence; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Conjugation; Free radicals; Full Article; Inorganic Chemistry; Intoxication; Laboratory animals; Liver; Malondialdehyde; Molecular chains; Organic Chemistry; Superoxide dismutase; Vitamin C; antiradical activity; ascorbic acid; toxic liver injury; pyrimidines; antioxidant activity
• ISSN: 1066-5285; 1573-9171
• DOI: 10.1007/s11172-018-2126-3

Antiradical activity and antioxidant properties of a conjugate of Xymedon with l -ascorbic acid were studied. In contrast to Xymedon, a conjugate of Xymedon with l -ascorbic acid was found to react with free radicals. Pro-oxidant activity of the conjugate of Xymedon with l -ascorbic acid in a chemiluminescence system is weaker as compared to individual l -ascorbic acid. This is the evidence of the increase in the stability of ascorbic acid upon conjugation with a molecule of Xymedon. Conjugate of Xymedon with l -ascorbic acid facilitates the decrease in the concentration of a lipid peroxidation product (malondialdehyde) and the activity of superoxide dismutase in liver and serum of laboratory animals exposed to intoxication with a known hepatotropic toxin CCl 4 . This observation shows the contribution of the antioxidant action to the hepatoprotective effect of the studied Xymedon derivative.