Synthesis of N-vinylpyrrolidone copolymers with 2-aminoethyl methacrylate as drug carriers

Radical copolymerization of N -vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride has been studied. Molecular and hydrodynamic characteristics of the resulting copolymers have been determined, and their structure has been confirmed. Conditions favoring conversion of these copolymers into c...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 87; no. 2; pp. 276 - 281
Main Authors Solovskii, M. V., Borisenko, M. S., Ershov, A. Yu, Zakharova, N. V., Tarabukina, E. B.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.02.2017
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copolymers
polymeric complex
ofloxacin
2-aminoethyl methacrylate
copolymer
vinylpyrrolidone
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Summary:Radical copolymerization of N -vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride has been studied. Molecular and hydrodynamic characteristics of the resulting copolymers have been determined, and their structure has been confirmed. Conditions favoring conversion of these copolymers into copolymers of N -vinylpyrrolidone with 2-aminoethyl methacrylate of different composition have been elucidated. The suitability of the prepared copolymers as polymeric carriers of monofluoroquinolone ofloxacin has been demonstrated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217020207