Influence of Polymers on the Physicochemical Properties of Benzonal in Solid Dispersions

• Published in: Moscow University chemistry bulletin Vol. 75; no. 6; pp. 388 - 390
• Main Authors: Krasnyuk, I. I., Beliatskaya, A. V., Stepanova, O. I., Kuzmenko, A. N., Lucenko, S. V., Kasimovskaya, N. A., Matyushin, A. A., Mazyarkin, E. V., Vorob’yov, A. N., Nesterenko, E. P.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.11.2020; Springer Nature B.V
• Subjects: Bioavailability; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Cyclodextrins; Dispersions; Dissolution; Polyethylene glycol; Polyvinylpyrrolidone; Solid solutions; Solubility; Solubilization; benzonal; solubility; polyvinylpyrrolidone (PVP); polyethylene glycol (PEG); β‑cyclodextrin; solid dispersions
• ISSN: 0027-1314; 1935-0260
• DOI: 10.3103/S0027131420060127

The influence of solid dispersions (SDs) on some physicochemical properties of benzonal is studied. Investigated: benzonal and its SD with polyvinylpyrrolidone-10 000 (PVP), polyethylene glycol-1500 (PEG), β-cyclodextrin (CD). The preparation of SD by the solvent removal method increases the solubility and dissolution rate of benzonal in water. The solubility increases by 3.5–5.5 times; and the speed of dissolving, by 4.0–10.0 times. The complex of physical and chemical research methods suggests that the preparation of an SD with the studied polymers is accompanied by loss of crystallinity and formation of a solid solution of benzonal in the polymer, as well as solubilization and formation of colloidal solutions of benzonal during subsequent dissolution of SD in water. The results obtained can be used in the development of fast-dissolving benzonal tablets with increased release and bioavailability.