Effects of Dietary Supplementation with Fish Scales-Derived Collagen Peptides on Skin Parameters and Condition: A Randomized, Placebo-Controlled, Double-Blind Study

Fish scales-derived collagen peptides (CPs) are characterized by their specific amino acid composition with a high concentration of glycine, proline and hydroxyproline. These amino acids have been known to exert beneficial effects on human skin. The aim of the present study was to examine the effect...

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Bibliographic Details
Published inInternational journal of peptide research and therapeutics Vol. 24; no. 3; pp. 397 - 402
Main Authors Koizumi, Seiko, Inoue, Naoki, Shimizu, Maiko, Kwon, Chang-ju, Kim, Hwa-young, Park, Kyoung Sik
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.09.2018
Springer Nature B.V
Subjects
Aging
Amino acid composition
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Blindness
Collagen
Dietary intake
Dietary supplements
Double-blind studies
Glycine
Histology
Hydroxyproline
Ingestion
Life Sciences
Molecular Medicine
Morphology
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Proline
Scales
Skin
Periorbital wrinkle
Collagen hydrolysate
Skin elasticity
Skin hydration
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Summary:Fish scales-derived collagen peptides (CPs) are characterized by their specific amino acid composition with a high concentration of glycine, proline and hydroxyproline. These amino acids have been known to exert beneficial effects on human skin. The aim of the present study was to examine the effects of collagen peptides obtained from fish scales on changes in periorbital wrinkles, facial skin hydration, and skin elasticity in healthy women aged 30–60 years. In the present randomized, placebo-controlled, double-blind trial, 71 subjects consumed a 20 mL beverage containing 3000 mg of CPs or placebo once per day over 12 weeks. Significant decreases in periorbital wrinkles ( p  < 0.05) were observed in the treatment group after 12 weeks of CPs ingestion compared to the control group. This study also demonstrated a consistent trend of enhanced facial skin moisture ( p  < 0.001) and skin elasticity ( p  < 0.001) by dietary intake of CPs without any side effects or adverse events. These findings indicate that fish-derived CPs hold great promise as a natural supplement with cutaneous anti-aging properties.
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-017-9626-0